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- Yasuhiro Tsuji, Masato Tashiro, Nobuyuki Ashizawa, Yukio Ota, Hayato Obi, Saori Nagura, Munetoshi Narukawa, Kazuaki Fukahara, Naoki Yoshimura, Hideto To, and Yoshihiro Yamamoto.
- Department of Medical Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Japan.
- Intern. Med. 2015 Jan 1;54(2):235-9.
AbstractThis study is the first case report of the treatment of methicillin-resistant Staphylococcus aureus (MRSA) mediastinitis using therapeutic drug monitoring of the serum and wound exudate concentrations of linezolid in a renal dysfunction patient. In the present study, the serum trough concentration of linezolid was maintained between 2 and 7 μg/mL. Therapeutic drug monitoring dosage adjustments may be especially useful in patients with renal dysfunction and severe MRSA infection.
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