• Felipe de Jesús Martín Pérez-Rada, María Teresa Macías-García, and Alicia Concepción Cataneo-Cerna.
• Unidad de Cuidados Intensivos, Hospital de Especialidades 25, Instituto Mexicano del Seguro Social, Monterrey, Nuevo León, Mexico. ac3_adrenalina@hotmail.com
• Rev Med Inst Mex Seguro Soc. 2012 Jul 1;50(4):419-26.

Objectiveto determine which drug dexmedetomidine or midazolam produces greater delirium in septic patients.Methodsobservational, analytical, comparative, prospective and longitudinal in 59 postsurgical patients both sexes, with mechanical ventilation (MV), sepsis, and sedation with dexmedetomidine or midazolam complicated with sepsis was done. We evaluated age, severity of sepsis with SOFA and APACHE. Complications associated with delirium were registered. The "t" Student test and χ(2) were used.ResultsMidazolam group, 33 patients, mean age 49.75 ± 19.48 years, SOFA 15.81 ± 7.48 points and APACHE 7.51 ± 5.41, delirium was present in 29 patients, days of MV 15.86 ± 14.12, reintubation rate 24 %, ICU stay 16.41 ± 14.41, hospital stay 28.58 ± 19.91 days and death rate 34.5 %. Dexmedetomidine group: 26 patients, mean age 49.57 ± 13.76 years, in SOFA 13.34 ± 7.66 points and 6.23 ± 4.51 in APACHE scale, delirium in 11 patients, days of MV 17.9 ± 12.53 and reintubation in 45.5 %, ICU days 14.36 ± 9.25, hospital stay 22.63 ± 14.87 and death in 36.4 %.Conclusionsdelirium was increased in complicated post-surgical patients with sepsis, mechanical ventilation and midazolam.

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