• Naiara Galvão da Silva, Alexandre Malta Brandão, Marcos Vinícius Melo de Oliveira, Pedro Henrique Alves de Morais, Silvana Marques e Silva, Fabiana Pirani Carneiro, and João Batista de Sousa.
• School of Medicine, UnB, Brasilia, DF, Brazil.
• Acta Cir Bras. 2011 Jan 1;26 Suppl 2:92-9.

PurposeTo evaluate the effects of metoclopramide on abdominal wall healing in rats in the presence of sepsis.Methods40 rats divided into two groups of twenty animals, subdivided into two subgroups of 10 animals each: group (E) - treated with metoclopramide, and saline-treated control group. The two groups were divided into subgroups of 10 to be killed on the 3rd day (n = 10) or day 7 (n = 10) after surgery. Sepsis was induced by cecal ligation and puncture. We performed also the section and anastomosis in left colon. The synthesis of the abdominal wall was made with 3-0 silk thread. We measured the breaking strength of the abdominal wall and made the histopathological evaluation.Resultson 3rd day postoperative, the average breaking strength in the E group was 0.83 ± 0.66 and in group C was 0.35 ± 0.46 (p = 0.010). On the seventh day, the breaking strength in group E was 11.44 ± 5.07, in group C 11.66 ± 7.38 (p = 1.000). The E7 group showed lower inflammatory infiltration, foreign body reaction, fibrin than control.Conclusionanimals treated with metoclopramide had a higher resistance of the abdominal wall on the 3rd postoperative day.

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