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- R R Dalton, J S Krauss, D G Falls, and G K Fuller.
- Department of Pathology, Medical College of Georgia, Augusta 30912, USA. rdalton@mail.mcg.edu
- Ann. Clin. Lab. Sci. 2001 Oct 1;31(4):365-8.
AbstractGranulocytic fragments have been described in the peripheral blood of patients with sepsis and the systemic inflammatory response syndrome (SIRS). Although initially proposed as a morphologic clue for distinguishing the leukoerythroblastosis of sepsis from that of myelophthisis or marrow replacement by tumor, granulocyte-derived fragments may be part of a spectrum of cellular fragmentation associated with pathological inflammation and thrombosis, and thus play an important role in the pathophysiology of sepsis and SIRS. Pathologists, hematologists, and medical technologists should be aware of their existence, the morphologic features that distinguish them from macrothombocytes and schistocytes, and their potential significance.
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