• Asian Cardiovasc Thorac Ann · Feb 2006

    Case Reports

    A lethal complication of propofol.

    • Hon Chi Suen, Robert J Haake, Victor M Chavez, and Sultan A Hayat.
    • Department of Cardiothoracic Surgery, Memorial Hospital, Belleville, USA. HSUEN@earthlink.net
    • Asian Cardiovasc Thorac Ann. 2006 Feb 1;14(1):60-2.

    AbstractHigh-dose propofol infusion for sedation of patients in the intensive care unit can result in rhabdomyolysis, acute renal failure, metabolic acidosis, hyperkalemia, ventricular arrhythmia, hyperthermia, and death. The death of a patient with such complications after lung biopsy is reported. Until a safer dosage range has been determined, propofol infusion at rates higher than 5 mg x kg(-1) x h(-1) should be discouraged for long-term sedation (> 48 h).

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