• Brian E Gulbis and Anne P Spencer.
• Medical University of South Carolina, Charleston, SC, USA. Brian.Gulbis@memorialhermann.org
• Ann Pharmacother. 2006 Oct 1;40(10):1797-803.

ObjectiveTo review the literature regarding the efficacy and safety of continuous intravenous infusion of loop diuretics following cardiac surgery.Data SourcesArticles were identified through a MEDLINE search (1966-March 2006) using the key words furosemide, bumetanide, torsemide, ethacrynic acid, loop diuretics, continuous infusions, intravenous infusions, surgery, cardiac surgery, cardiovascular surgery, and thoracic surgery. Search results were limited to studies in human subjects published in English. Additional references were identified through review of the bibliographies of the articles cited.Study Selection And Data ExtractionAll clinical trials and observational reports identified that evaluated or described the efficacy and/or safety of a continuous infusion of a loop diuretic in adult or pediatric patients who had undergone cardiac surgery were included in this review.Data SynthesisLoop diuretics are often used to promote diuresis following cardiac surgery. Studies in patients who have undergone cardiac surgery have demonstrated that a more consistent and sustained diuresis is produced by a continuous infusion of furosemide compared with intermittent bolus doses of furosemide. However, there does not appear to be a significant difference in total urine output or change in serum electrolyte levels when furosemide is administered as a continuous infusion compared with intermittent bolus doses.ConclusionsA continuous infusion of furosemide is an effective and safe method of diuresis in patients undergoing cardiac surgery.

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