• Curr Top Med Chem · Jan 2013

    Review

    An update on the chemistry and medicinal chemistry of novel antimycobacterial compounds.

    • Frederico Silva Castelo Branco, Angelo C Pinto, and Núbia Boechat.
    • Fundação Oswaldo Cruz (FIOCRUZ), Instituto de Tecnologia em Fármacos (Farmanguinhos), Departamento de Síntese de Fármacos, Laboratório de Síntese 1, Rua Sizenando Nabuco, 100, Manguinhos, CEP: 21041-250 - Rio de Janeiro, RJ - Brasil. boechat@far.fiocruz.br.
    • Curr Top Med Chem. 2013 Jan 1;13(22):2808-49.

    AbstractTuberculosis (TB) is a serious public health issue, particularly in underdeveloped and developing countries. Furthermore the first-line anti-TB treatments were established over 40 years ago, multidrug-resistant Mycobacterium tuberculosis strains have been developed and the risk of coinfection with AIDS virus has highlighted this disease as a global emergency. The urgent need for more effective treatments against multidrug-resistant strains compatible with anti-AIDS drugs has prompted industries, governments and non-governmental agencies to pursue new drugs. In this study, we update the portfolio listed at Stop TB Partnership, present the biological activities as well as structure-activity relationship for these drugs and thoroughly discuss the synthetic methodologies used to produce these drugs.

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