-
- Frederico Silva Castelo Branco, Angelo C Pinto, and Núbia Boechat.
- Fundação Oswaldo Cruz (FIOCRUZ), Instituto de Tecnologia em Fármacos (Farmanguinhos), Departamento de Síntese de Fármacos, Laboratório de Síntese 1, Rua Sizenando Nabuco, 100, Manguinhos, CEP: 21041-250 - Rio de Janeiro, RJ - Brasil. boechat@far.fiocruz.br.
- Curr Top Med Chem. 2013 Jan 1;13(22):2808-49.
AbstractTuberculosis (TB) is a serious public health issue, particularly in underdeveloped and developing countries. Furthermore the first-line anti-TB treatments were established over 40 years ago, multidrug-resistant Mycobacterium tuberculosis strains have been developed and the risk of coinfection with AIDS virus has highlighted this disease as a global emergency. The urgent need for more effective treatments against multidrug-resistant strains compatible with anti-AIDS drugs has prompted industries, governments and non-governmental agencies to pursue new drugs. In this study, we update the portfolio listed at Stop TB Partnership, present the biological activities as well as structure-activity relationship for these drugs and thoroughly discuss the synthetic methodologies used to produce these drugs.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*,_underline_or**bold**. - Superscript can be denoted by
<sup>text</sup>and subscript<sub>text</sub>. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3., hyphens-or asterisks*. - Links can be included with:
[my link to pubmed](http://pubmed.com) - Images can be included with:
 - For footnotes use
[^1](This is a footnote.)inline. - Or use an inline reference
[^1]to refer to a longer footnote elseweher in the document[^1]: This is a long footnote..