• J. Cardiothorac. Vasc. Anesth. · Feb 2001

    Comparative Study Clinical Trial

    Comparison of two sites of inflow pressure measurement during retrograde cerebral perfusion.

    • P G Loubser.
    • Department of Anesthesiology, Baylor College of Medicine and the Methodist Hospital, Houston, TX, USA.
    • J. Cardiothorac. Vasc. Anesth. 2001 Feb 1;15(1):35-9.

    ObjectiveTo determine whether internal jugular venous valves influence inflow pressure during retrograde cerebral perfusion.DesignProspective study.SettingCommunity hospital, university setting, single institution.ParticipantsTen patients undergoing reconstructive aortic arch surgery with profound hypothermic circulatory arrest.InterventionsDuring retrograde cerebral perfusion, inflow pressure was continuously measured at 2 separate sites relative to the left internal jugular venous valve (ie, superior vena cava inflow catheter [infravalvular pressure] and rostral left internal jugular vein [supravalvular pressure]).Measurements And Main ResultsInfravalvular pressure of 29.8 +/- 3.5 mmHg and supravalvular pressure of 22.7 +/- 0.8 mmHg were significantly different (mean difference, 7.1 +/- 3.6 mmHg; p = 0.041). In 8 patients, the pressure difference was <6 mmHg; whereas in 2 patients, the pressure difference was >20 mmHg. Bland and Altman analysis revealed 95% limits of agreement on mean bias of -12.9 to 27.8 mmHg.ConclusionInternal jugular venous valves can obstruct retrograde cerebral perfusion inflow, manifest by an inflow pressure difference between the superior vena cava and internal jugular vein. In the presence of competent internal jugular venous valves, measurement of inflow pressure in the superior vena cava may be an inaccurate estimate of actual cerebral perfusion pressure. Internal jugular vein pressure should be monitored to avoid inadvertent cerebral hypoperfusion.

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