• A Toninelli, C Agapiti, P Terenghi, N Latronico, and A Candiani.
• Cattedra di Anestesia e Rianimazione, Università degli Studi di Brescia.
• Minerva Anestesiol. 1995 Jan 1;61(1-2):9-14.

ObjectiveTo assess if low gastric intramucosal pH (pHi), in the first 24 hours from trauma, is an early risk index for organ failure in severe trauma.DesignProspective clinical study.SettingGeneral ICU in a university hospital.PatientsThirty-one consecutive trauma patients, aged 15 to 71 years (mean 34.2), 26 men and 5 women.Measurements And ResultsIn all patients pHi was measured using a gastric tonometer. All patients presented systemic inflammatory response syndrome (SIRS) and 14 patients (45.2%) developed sepsis. Seven patients developed one or more organ failures (22.6%). Six patients died (19.4%), five because of organ failure and one because of primary brain injury. The worst 12-24 hour pHi, the worst 24 hours blood Base Excess, APACHE II and ISS were grouped by absence or presence of sepsis, organ failure and by outcome. Patients developing organ failure had pHi values (median = 7.06) significantly lower than patients who did not developed organ failure (median = 7.33) (chi 2 = 5.35; p = 0.02).ConclusionsOur data suggest that low pHi during the first 24 hours from trauma seems to be a good predictor for the development of organ failure.

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