• Nippon Rinsho · Aug 2009

    Review

    [A novel therapeutic drug: ramelteon].

    • Masaomi Miyamoto.
    • Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited.
    • Nippon Rinsho. 2009 Aug 1;67(8):1595-600.

    AbstractCurrent treatment of insomnia with hypnotics, GABA(A) receptor modulators, induces various side effects, including cognitive impairment, motor disturbance, dependence, tolerance, hang-over, and rebound insomnia. Ramelteon (Rozerem) is an orally active, highly selective melatonin MT1/MT2 receptor agonist. Unlike the sedative hypnotics that target GABA(A) receptor complexes, ramelteon is a chronohypnotic that acts on the melatonin MT1 and MT2 receptors, which are primarily located in the suprachiasmatic nucleus. Ramelteon has demonstrated sleep-promoting effects in clinical trials, and coupled with its favorable safety profile and lack of abuse potential or dependence, this chronohypnotic provides an important treatment option for insomnia.

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