• Methods Mol. Biol. · Jan 2015

    Host response biomarkers in sepsis: overview on sTREM-1 detection.

    • Jérémie Lemarié, Damien Barraud, and Sébastien Gibot.
    • Department of Medical Intensive Care, Hôpital Central, 29 avenue du Maréchal de Lattre de Tassigny, 54035, Nancy Cedex, France.
    • Methods Mol. Biol. 2015 Jan 1;1237:225-39.

    AbstractThe diagnosis of sepsis, and especially its differentiation from sterile inflammation, may be challenging. TREM-1, the triggering receptor expressed on myeloid cells-1, is an amplifier of the innate immune response. Its soluble form acts as a decoy for the natural TREM-1 ligand and dampens its activation. In this chapter, we review the numerous studies that have evaluated the usefulness of sTREM-1 concentration determination for the diagnosis and the prognosis evaluation of sepsis or localized infection. Nowadays, sandwich ELISA kits are available and the assay is described.

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