• Artif Cells Blood Substit Immobil Biotechnol · Apr 2011

    Hemoglobin-based oxygen carrier (HBOC-201) and escalating doses of recombinant factor VIIa (rFVIIa) as a novel pre-hospital resuscitation fluid in a swine model of severe uncontrolled hemorrhage.

    • Anke Scultetus, Francoise Arnaud, Lewis Kaplan, Aryeh Shander, Nora Philbin, Jennifer Rice, Richard McCarron, and Daniel Freilich.
    • Operational and Undersea Medicine Directorate, NeuroTrauma Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA. anke.scultetus@med.navy.mil
    • Artif Cells Blood Substit Immobil Biotechnol. 2011 Apr 1;39(2):59-68.

    AbstractExsanguinating hemorrhage and unavailability of blood are major problems in pre-hospital trauma care. We investigated if combining rFVIIa with HBOC-201 reduces blood loss and improves physiologic parameters compared to HBOC alone. Swine underwent liver injury and were resuscitated with HBOC-201 alone or HBOC+90, 180 or 360 μg/kg rFVIIa before hospital arrival at 240 min; animals survived to 72 hours. Blood loss was reduced; MAP, CI, transcutaneous oxygen saturation, and 72-hour survival improved in the 90 and 180 μg/kg rFVIIa groups. Lactate was cleared faster in the HBOC+rFVIIa 90 μg/kg group. Verification in a large, well-powered study is indicated.

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