Artificial cells, blood substitutes, and immobilization biotechnology
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Artif Cells Blood Substit Immobil Biotechnol · Apr 2011
ReviewFilling materials used in kyphoplasty and vertebroplasty for vertebral compression fracture: a literature review.
Kyphoplasty (KP) and vertebroplasty (VP) are both minimally invasive surgical techniques, which can enhance the mechanical stability of the vertebral lesion by injecting filling materials into the fractured vertebra. The filling materials used in KP and VP include injectable PMMA, composite bone cement, biodegradable bone cement, calcium phosphate cement (CPC), and others. Different filling materials have different effects on the biomechanical properties of vertebral bodies, causing various biomechanical effects on the adjacent vertebral bodies. In conclusion, the development of filling materials can improve the anti-pressure capacity and effectively maintain good morphological characteristics of fractured vertebral bodies.
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Artif Cells Blood Substit Immobil Biotechnol · Apr 2011
Hemoglobin-based oxygen carrier (HBOC-201) and escalating doses of recombinant factor VIIa (rFVIIa) as a novel pre-hospital resuscitation fluid in a swine model of severe uncontrolled hemorrhage.
Exsanguinating hemorrhage and unavailability of blood are major problems in pre-hospital trauma care. We investigated if combining rFVIIa with HBOC-201 reduces blood loss and improves physiologic parameters compared to HBOC alone. ⋯ Lactate was cleared faster in the HBOC+rFVIIa 90 μg/kg group. Verification in a large, well-powered study is indicated.