• Vet. Clin. North Am. Food Anim. Pract. · Mar 2015

    Review

    Clinical pharmacology of analgesic drugs in cattle.

    • Matthew L Stock and Johann F Coetzee.
    • Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, 2448 Lloyd Vet Med, Ames, IA 50011, USA.
    • Vet. Clin. North Am. Food Anim. Pract. 2015 Mar 1;31(1):113-38, vi-vii.

    AbstractProviding pain relief in cattle is challenging. In the absence of labeled drugs, the Animal Medicinal Drug Use Clarification Act regulates the extralabel drug use of analgesics in cattle within the United States. Given the variety of pharmacokinetic and pharmacodynamic properties of pain-relieving drugs, evidence needs to drive the development of analgesic protocols for cattle during pain-related events. This article reviews the commonly used analgesics investigated in cattle including local anesthetics, nonsteroidal anti-inflammatory drugs, opioids, α2-agonists, N-methyl-d-aspartate receptor antagonists, and gabapentin. These compounds are examined with respect to evidence of analgesia in cattle during pain states.Copyright © 2015 Elsevier Inc. All rights reserved.

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