• Neuroscience · May 2016

    Review Meta Analysis

    Neural stem/progenitor cells transplantation for spinal cord injury treatment; a systematic review and meta-analysis.

    • M Yousefifard, V Rahimi-Movaghar, F Nasirinezhad, M Baikpour, S Safari, S Saadat, A Moghadas Jafari, H Asady, S M T Razavi Tousi, and M Hosseini.
    • Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
    • Neuroscience. 2016 May 13; 322: 377-97.

    AbstractDespite the vast improvements of cell therapy in spinal cord injury treatment, no optimum protocol has been developed for application of neural stem/progenitor cells. In this regard, the present meta-analysis showed that the efficacy of the neural stem/progenitor cell (NSPC) transplantation depends mainly on injury model, intervention phase, transplanted cell count, immunosuppressive use, and probably stem cell source. Improved functional recovery post NSPC transplantation was found to be higher in transection and contusion models. Moreover, NSPC transplantation in acute phase of spinal injury was found to have better functional recovery. Higher doses (>3×10(6)cell/kg) were also shown to be optimum for transplantation, but immunosuppressive agent administration negatively affected the motor function recovery. Scaffold use in NSPC transplantation could also effectively raise functional recovery.Copyright © 2016. Published by Elsevier Ltd.

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