• O Kaabachi, A Ben Rajeb, M Mebazaa, H Safi, C Jelel, M Ben Ghachem, and M Ben Ammar.
• Service d'orthopédie, hôpital d'enfants de Tunis, 1007 Tunis, Tunisie. olfa.kaabachi@rns.tn
• Ann Fr Anesth Reanim. 2002 Oct 1; 21 (8): 617-21.

ObjectiveTo evaluate the effect of intrathecal clonidine in children.Study DesignA prospective randomised study.Patients And Methods45 children, 6 to 15 years old, were randomised in two groups; receiving either 0.5% hyperbaric bupivacaine or 0.5% hyperbaric bupivacaine added to clonidine 2 micrograms.kg-1. We assessed quality and length of motor and sensory blocks and side effects of clonidine: hypotension, bradycardia and sedation.ResultsClonidine was associated with prolongation of motor block. 190 +/- 42 min vs 150 +/- 35 min (p < 0.01), but the difference was not significant. Postoperative analgesia was longer in clonidine group, 490 +/- 35 min vs 200 +/- 50 min (mean +/- SD), p < 0.001. Clonidine was associated with higher incidence of hypotension 54 vs 36% and bradycardia 30 vs 0%.ConclusionThese data suggest that intrathecal clonidine 2 micrograms.kg-1 is associated with extending duration of postoperative analgesia but with moderate side effects.

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