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Clin Neuropharmacol · Jul 2005
Randomized Controlled TrialBotulinum toxin and intractable trigeminal neuralgia.
- Ulkü Türk, Selen Ilhan, Recep Alp, and Haydar Sur.
- Department of Neurology, Dr. Lütfi Kirdar Kartal Research and Education Hospital, Istanbul, Turkey. uturkboru@hotmail.com
- Clin Neuropharmacol. 2005 Jul 1;28(4):161-2.
AbstractThe effects of botulinum toxin have been demonstrated in pain syndromes such as migraine, tension headache, and postherpetic neuralgia. With this background data in hand, the authors planned a randomized, open-ended study to investigate the efficacy of botulinum injections in cases of refractory trigeminal neuralgia. In 8 patients with trigeminal neuralgia, 100 U botulinum toxin was injected into the region of the zygomatic arch. The results of their statistical analyses demonstrated that the medication can be effective in treating trigeminal neuralgia. The patients did not develop any significant adverse effects. Botulinum toxin can be used in the treatment of refractory trigeminal neuralgia.
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