• Paediatric anaesthesia · Jun 2004

    Randomized Controlled Trial Comparative Study Clinical Trial

    A comparison between single- and double-breath vital capacity inhalation induction with 8% sevoflurane in children.

    • Kok-Yuen Ho, Wee-Leng Chua, Serene S T Lim, and Agnes S B Ng.
    • Department of Anaesthesia (Paediatrics), KK Women's and Children's Hospital, Singapore. hokokyuen@yahoo.com.sg
    • Paediatr Anaesth. 2004 Jun 1;14(6):457-61.

    BackgroundThis study was conducted to determine if a double-breath (DB) vital capacity (VC) rapid inhalation induction using immediate high-inspired concentration of sevoflurane is as well tolerated as a single-breath (SB) technique and if it results in a shorter induction time.MethodsA total of 104 children, ASA I-II, 6 year and above, undergoing elective surgery were randomly assigned to two groups: SB VC inhalation induction or DB VC inhalation induction with 8% sevoflurane in 66% nitrous oxide. The induction time, complications (cough, laryngospasm, breath-hold, movement, salivation) and level of satisfaction were documented.ResultsInduction was significantly faster in the DB group (41 +/- 9 s) compared with the SB group (50 +/- 14 s). DB inhalation induction was associated with fewer complications (15.4%) than the SB technique (50%).ConclusionsDouble-breath VC inhalation induction with 8% sevoflurane is as well tolerated as a SB technique and results in a faster onset of anaesthesia.

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