• G Paredes and C Cevallos.
• Unidad de Cuidados Intensivos, Hospital Enrique Garcés, Quito, Ecuador. rogergustavo26@hotmail.com
• Med Intensiva. 2010 Jun 1;34(5):310-7.

ObjectiveAmong the most severe complications caused by the influenza A virus H1N1 pandemic is the Acute Respiratory Distress Syndrome (ARDS). The main objective of this study was to assess mortality after applying a strict protocol of ventilatory management and to describe the clinical characteristics of the patients.DesignA prospective cohort study.SettingIntensive care unit (ICU) of the Hospital Enrique Garcés of the City of Quito.PatientsPatients admitted to the ICU with a diagnosis of severe pneumonia, ARDS, and high suspicion of influenza A H1N1.Primary Variables Of InterestDemographic variables, severity, diagnostic scores of community-acquired pneumonia, ventilator management protocol and mortality at 28 days, as principal effect of the study, were collected.Results24 patients were studied, 100% with a diagnosis of ARDS, mean age 41.1 (+/-14.8). Severe viral pneumonia predominated in these patients, mean APACHE was 18, average PaO(2)/FiO(2) on admission was 74.9, 100% had multisystemic involvement. A total of 91.3% received oseltamivir 150 mg w/12h for 14 days, the mean time between onset of symptoms and antiviral administration was 6.74 days. Intra-ICU mortality was 16.6%, and 28 days was 16.6%.ConclusionsAfter applying a strict management protocol for ventilatory management, mortality in this patient group was 16.6. We also stress that obesity and early renal failure were independent risk factors for mortality.Copyright (c) 2009 Elsevier España, S.L. y SEMICYUC. All rights reserved.

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