Medicina intensiva
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Severe sepsis and septic shock are conditions associated with high morbidity and mortality. The disproportionate release of pro-inflammatory and anti-inflammatory mediators caused by the septic insult is the promoter of multiple organ dysfunction. ⋯ In this setting, a higher dose of ultrafiltration (> 50 ml/kg/h) or "septic dose" may be needed. In this review article, we have analyzed the clinical and pathophysiological rationale for the use of high volume hemofiltration in patients with septic shock.
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The second most important infectious complication in hospitalized patients is pneumonia, this occupying the first place in the Intensive Care Units (ICU). Approximately 80% of the episodes of nosocomial pneumonia occur in patients with an artificial airway, which is called ventilation-associated pneumonia (VAP). VAP is the most frequent cause of mortality among nosocomial infections in the ICU, mainly if they are caused by Pseudomonas aeruginosa and Methicillin-resistant Staphylococcus aureus (MRSA). ⋯ We should also evaluate the patient's condition and the risk factors for difficult-to-treat pathogens. If the VAP is early and there are no risk factors, most of the empiric antibiotic strategies will provide correct coverage of the flora found. However, if the diagnosis of VAP is made in a patient who has been receiving mechanical ventilation for more than one week, under antibiotic use, with risk factors for multi-resistant pathogens, we should individualize the empiric antibiotic treatment.
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Among the most severe complications caused by the influenza A virus H1N1 pandemic is the Acute Respiratory Distress Syndrome (ARDS). The main objective of this study was to assess mortality after applying a strict protocol of ventilatory management and to describe the clinical characteristics of the patients. ⋯ After applying a strict management protocol for ventilatory management, mortality in this patient group was 16.6. We also stress that obesity and early renal failure were independent risk factors for mortality.
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The prevention of ventilator-associated pneumonia (VAP) is a priority in the Intensive Care Unit (ICU). To achieve this goal, clinical practice guidelines recommend the simultaneous application of a heterogeneous group of preventive measures of proven effectiveness. That is why we are presently seeing a reduction in VAP incidence to values previously considered unreachable. ⋯ A serious drawback of DDS is the risk of favoring the selection of resistant microorganisms that can spread easily through the ICU and the hospital. With current standards of infection prevention, DDS is an unnecessary and risky measure, which should not be used on a widespread basis. Those situations in which the DDS may increase the effectiveness of properly implemented standard measures are still unknown.
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Selective decontamination of the digestive tract (SDD) has been proven to prevent infections of endogenous development and reduce mortality in critically ill patients under prolonged mechanical ventilation. Historical arguments against its use, like the development of bacterial resistance or the selection of resistant microorganisms and the absence of influence on mortality have not been confirmed. Moreover, recent clinical trials designed to evaluate these variables, show remarkable reductions in the incidence of resistant bacteria and a significant beneficial effect on mortality. ⋯ In order to facilitate the use of SDD in the critically ill, this preventive measure should be incorporated in guidelines of national and international scientific societies and working groups involved in the care of the critically ill patient. The general implementation of SDD in our intensive care units must be accompanied by a registry in order to be able to monitor the effect on the incidence of infection and bacterial resistance. For this purpose, the Spanish national ICU infection and resistance surveillance programme ENVIN-HELICS, active over the last 15 years, constitutes both a more than adequate tool, and the convenient reference data base.