• Huang Tiancha, Wang Huiqin, Jing Jiyong, Jin Jingfen, and Cui Wei.
• Intensive Care Unit, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
• Scand. J. Infect. Dis. 2011 Jul 1;43(6-7):436-47.

BackgroundWe evaluated the association of lymphotoxin-α (LTA, also known as tumour necrosis factor-β) promoter +252 A/G polymorphism with sepsis.MethodsA systematic search was performed in MEDLINE, EMBASE, and Web of Science (for the period January 1966 to June 2010). Two reviewers independently selected studies on the genetic association of LTA +252 A/G polymorphism with sepsis and independently extracted data onto standardized forms.ResultsTwenty-seven studies with 4399 septic patients were included based on predefined inclusion criteria. As compared to AG + GG, the LTA AA genotype was significantly associated with an increased development of sepsis in the overall population (odds ratio (OR) 1.33, 95% confidence interval (CI) 1.09-1.62; p = 0.006). An association between mortality from sepsis and AA genotype was also found in the overall population (OR 1.89, 95% CI 1.27-2.80; p = 0.002). Stratification by ethnicity indicated that the contribution to both sepsis susceptibility and mortality may be stronger in Caucasians (OR 1.44, 95% CI 1.08-1.91 and OR 2.47, 95% CI 1.52-4.00, respectively) than in other ethnicities.ConclusionsThe LTA +252 A/G polymorphism is associated with both susceptibility to and mortality from sepsis.

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