Scandinavian journal of infectious diseases
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Scand. J. Infect. Dis. · Jul 2011
Meta AnalysisAssociation between lymphotoxin-α intron +252 polymorphism and sepsis: a meta-analysis.
We evaluated the association of lymphotoxin-α (LTA, also known as tumour necrosis factor-β) promoter +252 A/G polymorphism with sepsis. ⋯ The LTA +252 A/G polymorphism is associated with both susceptibility to and mortality from sepsis.
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Scand. J. Infect. Dis. · Jul 2011
Case ReportsTransient natural killer deficiency in a boy with herpes simplex virus-associated recurrent erythema multiforme.
Erythema multiforme is characterized by itching macules, papules and bullae, symmetrically distributed on the dorsum of the hands. They can follow the administration of several drugs or infections with various agents, and in particular with herpes simplex virus. The recurrent variant is very rare, especially in the paediatric age group. We describe the case of a male adolescent with recurrent erythema multiforme caused by herpes virus and transient natural killer deficiency.
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Scand. J. Infect. Dis. · Jul 2011
Elevated procalcitonin predicts Gram-negative sepsis in haematological patients with febrile neutropenia.
To compare semi-quantitative procalcitonin with C-reactive protein in predicting bacteraemia in haematological patients with neutropenic fever. ⋯ An elevated level of procalcitonin within 24 h after the onset of neutropenic fever predicts bacteraemia and Gram-negative bacteraemia in haematological patients.
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Scand. J. Infect. Dis. · Jul 2011
Serious bacterial infections in hospitalized febrile infants aged 90 days or younger: the traditional combination of ampicillin and gentamicin is still appropriate.
A change in the bacterial epidemiology of infantile serious bacterial infection (SBI) has raised concerns regarding the appropriate empirical antibiotic therapy. ⋯ Despite changes in the epidemiology of infantile SBI, the traditional combination of ampicillin and gentamicin is still appropriate for empirical treatment of febrile infants aged ≤ 90 days.
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Scand. J. Infect. Dis. · Jul 2011
Failure of combination oral oseltamivir and inhaled zanamivir antiviral treatment in ventilator- and ECMO-treated critically ill patients with pandemic influenza A (H1N1)v.
The objective of this study was to describe the clinical course of severe and complicated pandemic (H1N1)v infection treated with oral oseltamivir and inhaled zanamivir in a series of intensive care patients. ⋯ The mortality in these patients was high despite combined antiviral treatment with oseltamivir and zanamivir. Patients shed virus for a long time despite intensive therapy. Optimal management of patients with bilateral pneumonia and respiratory failure caused by (H1N1)v still needs to be determined.