• Giorgio Costantino, Francesca Perego, Franca Dipaola, Marta Borella, Andrea Galli, Giulia Cantoni, Simonetta Dell'Orto, Simonetta Dassi, Nicola Filardo, Pier Giorgio Duca, Nicola Montano, Raffaello Furlan, and STePS Investigators.
• Syncope Unit, Internal Medicine II, L. Sacco Hospital, University of Milan, Milan, Italy.
• J. Am. Coll. Cardiol. 2008 Jan 22;51(3):276-83.

ObjectiveWe sought to assess short- and long-term prognosis of syncope and associated risk factors.BackgroundSyncope is a common clinical event, but our knowledge of its short-term outcome is largely incomplete. Further, it is unknown whether hospital admission might positively affect a patient's syncope prognosis.MethodsWe screened 2,775 consecutive subjects who presented for syncope at 4 emergency departments between January and July 2004. Short- and long-term severe outcomes (i.e., death and major therapeutic procedures) and related risk factors were compared in all enrolled patients arrayed according to hospital admission or discharge.ResultsA total of 676 subjects were included in the study. Forty-one subjects (6.1%) experienced severe outcomes (5 deaths, 0.7%; 36 major therapeutic procedures, 5.4%) in the 10 days after presentation. An abnormal electrocardiogram, concomitant trauma, absence of symptoms of impending syncope, and male gender were associated with short-term unfavorable outcomes. Long-term severe outcomes were 9.3% (40 deaths, 6.0%; 22 major therapeutic procedures, 3.3%), and their occurrence was correlated with an age >65 years, history of neoplasms, cerebrovascular diseases, structural heart diseases, and ventricular arrhythmias. Short-term major therapeutic procedures were more common (p < 0.05) in subjects who had been admitted to hospital (13.3%) than in discharged (1.6%), whereas mortality was similar. One-year mortality was greater (p < 0.05) in admitted (14.7%) than in discharged (1.8%) patients.ConclusionsRisk factors for short- and long-term adverse outcomes after syncope differed. Hospital admission favorably influenced syncope short term prognosis. Instead, 1-year mortality was unaffected by hospital admission and related to comorbidity.

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