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- Paula H B Bolton-Maggs.
- University of Manchester, Manchester Blood Centre, Plymouth Grove, Manchester, UK. paula.bolton-maggs@manchester.ac.uk
- Pediatr Blood Cancer. 2013 Jan 1;60 Suppl 1:S37-40.
AbstractThe rare inherited coagulation disorders (RICD) are uncommon and thus not well-defined in terms of severity or management. Inheritance is autosomal; in some of these disorders in the heterozygote state affected individuals may be mildly symptomatic. Severe deficiencies are more common in association with consanguinity. Factor X and factor XIII deficiency have the most severe manifestations, while factor XI deficiency is the least severe. Factor VII and factor XI deficiencies show a poor relationship between the factor level and bleeding risk. Unlike hemophilia, women are equally affected by these RICD and can have problems related to menstruation and childbirth.Copyright © 2012 Wiley Periodicals, Inc.
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