• B Jung, J Carr, G Chanques, M Cisse, P-F Perrigault, A Savey, J-Y Lefrant, A Lepape, and S Jaber.
• Département d'anesthésie-réanimation Saint-Éloi, CHU de Montpellier, 80 avenue Augustin-Fliche, Montpellier, France.
• Ann Fr Anesth Reanim. 2011 Feb 1;30(2):105-12.

ObjectivesTo describe the demographic characteristics, incidence of extra-abdominal hospital-acquired infections and outcome of patients admitted to intensive care unit (ICU) with severe acute pancreatitis.Study DesignA retrospective, observational multiple center (65 centers) analysis of prospectively acquired data.Patients And MethodsDuring 2 years, all consecutive admitted patients to ICU for severe acute pancreatitis in the centers participating in the nosocomial infections surveillance network CClin Sud-Est were included. Patients whose ICU stay was less than 48 hours were not included. Demographic characteristics, extra-abdominal hospital-acquired infections and clinical course were described.ResultsDuring the study period, 510 patients were included which represented 2 % of patients with a length of stay longer than 48 hours in the 65 participating ICUs. The global attack rate of extra-abdominal hospital-acquired infections (pneumonia, bacteremia, urinary tract or central venous catheter infection) was 23 % in overall patients and it was 33 % in the 294 mechanically ventilated patients. ICU mortality was 20 % in overall patients and it was 34 % in mechanically ventilated patients.ConclusionSevere acute pancreatitis represents 2 % of ICU stay longer than 48 hours. Its clinical course is frequently complicated by hospital-acquired infections and is associated with an high ICU mortality rate. This epidemiological observational study may be used for calculating sample size for future multicenter interventional therapeutic studies.Copyright © 2011 Elsevier Masson SAS. All rights reserved.

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