• Ann Fr Anesth Reanim · Jun 2014

    Guideline

    [Storing succinylcholine in prehospital settings following the recommendations of the French National Agency for the safety of medicines.]

    • H Lefort, A Mendibil, S Margerin, A-C Cuquel, D Jost, K Tazarourte, L Domanski, J-P Tourtier, and l'Agence nationale de santé et du médicament.
    • Service médical d'urgence, brigade de sapeurs-pompiers de Paris, 3, rue Darmesteter, 75013 Paris, France. Electronic address: hdlefort@gmail.com.
    • Ann Fr Anesth Reanim. 2014 Jun 1;33(6):395-9.

    ObjectiveThe French National Pharmaceuticals Agency (ANSM) has recommanded in July 2012 not to break the cold chain before using succinylcholine (Celocurine®).Research Objectiveto understand the pre-clinical evolution of the conservation modes of this curare.Research TypeDescriptive study before (year 2011) and after (year 2012).Patients And MethodOnline survey to French Samu/Smur.Data CollectedSMUR location, conservation method at clinical base, in the mobile unit (UMH) and at the patient. Principal decision criteria: evolution of the conservation modes before and after the recommendation (qualitatives variables compared with a Fisher test).ResultsOut of 101 SAMU/SMUR, 62 answered. Conservation modes of succinylcholine vials were significantly different (P<0.001). Proper conservation was observed in 26 % of the cases before and 43 % after. Mobile units (UMH) equipped with a fridge increased from one out of two to 77 %. The lack of conservation modes passive or active on UMH went from 31 % to 3.4 % with isotherms bags with ice when a fridge was not available. The destruction of capsules at current temperature in a 24-hour period increased: 22 % before, 47 % after (P=0.04).ConclusionAfter recommendations from ANSM, conservation modes and destruction of succinylcholine in a prehospital environment were significantly impacted.Copyright © 2014 Société française d’anesthésie et de réanimation (Sfar). Published by Elsevier SAS. All rights reserved.

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