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Comparative Study
High-flow nasal cannula as a device to provide continuous positive airway pressure in infants.
- K L Spence, D Murphy, C Kilian, R McGonigle, and R A Kilani.
- Division of Newborn Medicine, the Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis Children's Hospital, St Louis, MO, USA. spence_k@kids.wustle.edu
- J Perinatol. 2007 Dec 1;27(12):772-5.
ObjectiveTo measure the intrapharyngeal pressure (IPP) generated by high-flow nasal cannula (HFNC) at varying flow rates up to 5 l min(-1).Study DesignWe studied 14 infants on HFNC or NCPAP using IPP manometry to measure the IPP generated at flows of 1, 2, 3, 4 and 5 l min(-1).ResultOn average flow rates of 1, 2, 3, 4 and 5 l min(-1) generated an IPP (cm of H(2)O) of 1.70+/-0.34, 1.75+/-0.2, 2.62+/-0.28, 3.78+/-0.44 and 4.84+/-0.51 respectively.ConclusionHFNC delivers significant IPP and is potentially a well-tolerated and viable option to provide CPAP at flows of > or = 3 min(-1) in infants with respiratory distress.
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