• J. Neurol. Neurosurg. Psychiatr. · Mar 2008

    Randomized Controlled Trial

    Gabapentin for prevention of hypobaric hypoxia-induced headache: randomized double-blind clinical trial.

    • S Jafarian, R Abolfazli, F Gorouhi, S Rezaie, and J Lotfi.
    • Department of Neurology, Shariati Hospital, Medical Sciences/University of Tehran, Tehran, Iran. jafarian_s@yahoo.com
    • J. Neurol. Neurosurg. Psychiatr. 2008 Mar 1;79(3):321-3.

    BackgroundHigh-altitude headache (HAH) is a hypobaric hypoxia-induced symptom that is commonly experienced by newcomers to high-altitude areas.ObjectiveTo assess the efficacy of gabapentin in the prevention of HAH.MethodsA placebo-controlled randomised trial was performed at an altitude of 3500 m. Two hundred and four unacclimatised 15-65-year-old (mean age (+/-SD), 31.5 (SD 11.7)) hotel guests were randomly assigned to a 600 mg single-dose of gabapentin capsule or identical placebo. HAH incidence and intensity were measured to assess gabapentin efficacy. Intention-to-treat analysis was performed.ResultsHAH incidence was not significantly different between subjects under gabapentin (44 (43.1%)) compared with placebo (56 (54.9%); p = 0.09). In contrast, moderate/severe HAH had a lower incidence in the gabapentin group (27 (26.5%)) versus the placebo group (42 (41.2%)), showing that gabapentin reduced HAH attack intensity (p = 0.03).ConclusionsGabapentin was effective for the prevention of HAH and had satisfactory tolerability.Trial Registration NumberISRCTN26123577.

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