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- Ashraf S Habib and Tong J Gan.
- Department of Anesthesiology, Duke University Medical Center, Box 3094, Durham, NC 27710, USA.
- Expert Opin Pharmacother. 2003 Apr 1;4(4):457-73.
AbstractPostoperative nausea and vomiting (PONV) are two of the most common and unpleasant side effects following anaesthesia and surgery. Despite the development of new anti-emetics and a vast amount of published research, PONV continues to be a problem, especially in high-risk patients. Recent interest has focused on the use of a combination of agents, acting on different receptors and the adoption of a multimodal approach to tackle this problem. The search for the most cost-effective strategy has also been a major goal. This article will discuss the risk factors and physiology of PONV, currently available therapies, the use of a multimodal approach and the cost-effectiveness of PONV management. Finally, recommendations for the prophylaxis and treatment of PONV will be discussed.
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