• Anne Nicollier-Fahrni, John-Paul Vader, Florian Froehlich, Jean-Jacques Gonvers, and Bernard Burnand.
• Institute of Social and Preventive Medicine, University of Lausanne, Lausanne, Switzerland.
• Int J Qual Health Care. 2003 Feb 1;15(1):15-22.

ObjectivesTo assess the degree of agreement between appropriateness criteria for the use of colonoscopy developed by a standardized expert panel method and evidence from published studies.DesignDescriptive, agreement study.SettingMultidisciplinary panel; primary care practice in Switzerland.ParticipantsNine national experts; 577 primary care patients referred for colonoscopy, 154 published papers.InterventionsEvaluation of the appropriateness of 402 possible clinical indications for colonoscopy, based on a comprehensive review of the literature.Main Outcomes MeasuresProportion of agreement (weighted kappa), between panel- and literature-based appropriateness categories (appropriate, uncertain, inappropriate) for theoretical and actual indications encountered.ResultsNineteen of 402 indications rated by the panel could be based on the evidence retrieved from eight randomized clinical trials. A 68% agreement (kappa = 0.52) was found between panel- and study-based criteria. The addition of an uncontrolled trial and seven observational studies yielded a 71% agreement (kappa = 0.63). Agreement was similar when examining 577 actual cases: 69% agreement, kappa = 0.47. Agreement between panel-based indications and published evidence was not influenced by the perceived comprehensiveness and the apparent quality of the published reports.ConclusionsEvidence for the appropriateness of most indications for colonoscopy could not be derived directly from the published literature. Agreement between appropriateness criteria developed by an expert panel and evidence from published studies was moderate to good, where available. New approaches should be sought in order to systematically integrate complementary evidence obtained from clinical trials and expert panels into practice guidelines.

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