• Amber E Barnato, Chung-Chou H Chang, Max H Farrell, Judith R Lave, Mark S Roberts, and Derek C Angus.
• Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. aeb2@pitt.edu
• Med Care. 2010 Feb 1;48(2):125-32.

BackgroundConcern regarding wide variations in spending and intensive care unit use for patients at the end of life hinges on the assumption that such treatment offers little or no survival benefit.ObjectiveTo explore the relationship between hospital "end-of-life" (EOL) treatment intensity and postadmission survival.Research DesignRetrospective cohort analysis of Pennsylvania Health Care Cost Containment Council discharge data April 2001 to March 2005 linked to vital statistics data through September 2005 using hospital-level correlation, admission-level marginal structural logistic regression, and pooled logistic regression to approximate a Cox survival model.SubjectsA total of 1,021,909 patients > or =65 years old, incurring 2,216,815 admissions in 169 Pennsylvania acute care hospitals.MeasuresEOL treatment intensity (a summed index of standardized intensive care unit and life-sustaining treatment use among patients with a high predicted probability of dying [PPD] at admission) and 30- and 180-day postadmission mortality.ResultsThere was a nonlinear negative relationship between hospital EOL treatment intensity and 30-day mortality among all admissions, although patients with higher PPD derived the greatest benefit. Compared with admission at an average intensity hospital, admission to a hospital 1 standard deviation below versus 1 standard deviation above average intensity resulted in an adjusted odds ratio of mortality for admissions at low PPD of 1.06 (1.04-1.08) versus 0.97 (0.96-0.99); average PPD: 1.06 (1.04-1.09) versus 0.97 (0.96-0.99); and high PPD: 1.09 (1.07-1.11) versus 0.97 (0.95-0.99), respectively. By 180 days, the benefits to intensity attenuated (low PPD: 1.03 [1.01-1.04] vs. 1.00 [0.98-1.01]; average PPD: 1.03 [1.02-1.05] vs. 1.00 [0.98-1.01]; and high PPD: 1.06 [1.04-1.09] vs. 1.00 [0.98-1.02]), respectively.ConclusionsAdmission to higher EOL treatment intensity hospitals is associated with small gains in postadmission survival. The marginal returns to intensity diminish for admission to hospitals above average EOL treatment intensity and wane with time.

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