• C C Roehr, H Proquitté, H Hammer, R R Wauer, C J Morley, and G Schmalisch.
• Clinic for Neonatology, Charité Universitätsmedizin Berlin, Berlin, Germany. christoph.roehr@charite.de
• Arch. Dis. Child. Fetal Neonatal Ed. 2011 Sep 1;96(5):F371-3.

ObjectiveEarly continuous positive airway pressure (CPAP) may reduce lung injury in preterm infants.Patients And MethodsSpontaneously breathing preterm infants were randomised immediately after birth to nasal CPAP or intubation, surfactant treatment and mechanical ventilation. Pulmonary function tests approximately 8 weeks post-term determined tidal breathing parameters, respiratory mechanics and functional residual capacity (FRC).ResultsSeventeen infants received CPAP and 22 mechanical ventilation. Infants with early CPAP had less mechanical ventilation (4 vs 7.5 days; p=0.004) and less total respiratory support (30 vs 47 days; p=0.017). Post-term the CPAP group had lower respiratory rate (41 vs 48/min; p=0.007), lower minute ventilation (223 vs 265 ml/min/kg; p=0.009), better respiratory compliance (0.99 vs 0.82 ml/cm H(2)O/kg; p=0.008) and improved elastic work of breathing (p=0.004). No differences in FRC were found.ConclusionsEarly CPAP is feasible, shortens the duration of respiratory support and results in improved lung mechanics and decreased work of breathing.

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