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Arzneimittel Forsch · Jan 2002
ReviewMode of action of gabapentin in chronic neuropathic pain syndromes. A short review about its cellular mechanisms in nociceptive neurotransmission.
- Rainer Surges and Thomas J Feuerstein.
- Sektion Klinische Neuropharmakologie, Neurologische Universitätsklinik Freiburg/Breisgau, Germany.
- Arzneimittel Forsch. 2002 Jan 1;52(8):583-6.
AbstractGabapentin (GBP, CAS 60142-96-3) has anticonvulsant and antinociceptive properties; the latter relate especially to chronic neuropathic pain. The mode of action of GBP, possibly different in epilepsy and chronic pain syndromes, is only poorly understood. This minireview is aimed at compiling the different mechanisms by which GBP may diminish the nociceptive transmission in the dorsal horn of the spinal cord.
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