• K Henderson, N F Sethna, and C B Berde.
• Department of Anaesthesia, Harvard Medical School, Boston, MA.
• J Clin Anesth. 1993 Mar 1;5(2):129-33.

Study ObjectiveTo determine the feasibility of continuous caudal anesthesia with 2-chloroprocaine in conscious former preterm infants undergoing inguinal hernia repair.DesignProspective study.SettingUniversity-affiliated children's hospital.PatientsTen former preterm infants, ASA physical status II and III, who were 35 to 49.5 weeks postconceptional age at the time of surgery.InterventionsCaudal anesthesia was administered via an indwelling catheter using a loading dose of 1 ml/kg (30 mg/kg) of 3% 2-chloroprocaine, followed by incremental doses of 0.3 ml/kg (9 mg/kg) to achieve a level of T4 to T2. The block was maintained by a minimum infusion rate of 30 mg/kg/hr (1 ml/kg/hr) of the same local anesthetic solution.Measurements And Main ResultsThe mean cumulative dose of 2-chloroprocaine was 2.8 +/- 1.0 ml/kg/hr (84 +/- 30 mg/kg/hr) infused over a mean duration of 95 +/- 35 minutes. Serum cholinesterase concentration and plasma 2-chloroprocaine concentration were measured in five infants.ConclusionsThree percent 2-chloroprocaine can be used effectively for continuous caudal anesthesia in conscious, former preterm infants for inguinal hernia and penoscrotal surgical procedures lasting 85 to 170 minutes.

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