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Randomized Controlled Trial Clinical Trial
Diamorphine analgesia after caesarean section. Comparison of intramuscular and epidural administration of four dose regimens.
- I D Smith, K E Klubien, M L Wood, D J Macrae, and F Carli.
- Department of Anaesthesia, Northwick Park Hospital, Harrow, Middlesex.
- Anaesthesia. 1991 Nov 1;46(11):970-3.
AbstractIn a randomised double-blind study, the efficacy, duration of action and side effects of five diamorphine analgesia regimens following Caesarean section are described. The time to next analgesia was shorter in the 5 mg intramuscular group (3.53 hours) than in any of the four epidural groups: 5 mg (5.7 hours, p = 0.007), 2.5 mg (4.76 hours, p = 0.103), 5 mg with adrenaline 1/200,000 (7.2 hours, p = 0.001) and 2.5 mg with adrenaline 1/200,000 (6.05 hours, p = 0.007). Multiple regression analysis showed that the addition of adrenaline significantly increased the duration of action of epidural diamorphine (p less than 0.05). The 5 mg dose with adrenaline showed no advantage when compared with 2.5 mg with adrenaline (p = 0.16). No serious side effects were reported in any group.
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