• Jonathon M Brown, Yuthana Udomphorn, Pilar Suz, and Monica S Vavilala.
• Department of Biomedical Sciences, Medical Sciences Programs, Drexel University College of Medicine, Philadelphia, PA 19104, USA.
• Childs Nerv Syst. 2008 Apr 1;24(4):477-83.

ObjectiveThe purpose of this study was to describe the treatment of noninfectious fever in children with severe traumatic brain injury (TBI).Materials And MethodsWe conducted a retrospective study to compare type of and response to antipyretic treatment strategies in children less than or equal to 17 years and Glasgow Coma Scale (GCS) score less than 9.ResultsThe average admission GCS score was 4. Forty children (35 boys, 5 girls), age 7.8 +/- 5.2 years, had noninfectious fever. Seventy percent (28 of 40) received acetaminophen only, and 30% (12 of 40) received acetaminophen plus either ibuprofen or physical cooling. Time to next febrile episode was longer in patients receiving combination therapy than those receiving monotherapy (p = 0.03). Fever refractory to treatment dose or strategy occurred in more than 40% of the patients.ConclusionsEarly combination antipyretic therapy may be needed to effectively maintain normothermia in children with severe TBI.

24 keywords...

hide…