• Metabolic brain disease · Apr 2015

    Review

    Intracerebral hemorrhage in mouse models: therapeutic interventions and functional recovery.

    • Balachandar Kathirvelu and S Thomas Carmichael.
    • Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA, bkathirvelu@ucla.edu.
    • Metab Brain Dis. 2015 Apr 1;30(2):449-59.

    AbstractThere has been strong pre-clinical research on mechanisms of initial cell death and tissue injury in intracerebral hemorrhage (ICH). This data has led to the evaluation of several therapeutics for neuroprotection or the mitigation of early tissue damage. Most of these studies have been done in the rat. Also, there has been little study of the mechanisms of tissue repair and recovery. This review examines the testing of candidate therapeutics in mouse models of ICH for their effect on tissue protection and repair. This review will help the readers compare it to the extensively researched rat model of ICH and thus enhance work that are pending in mouse model.

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