• Karen Brasel, Donna McRitchie, Patch Dellinger, and EBRS Group.
• EBRS, Mount Sinai Hospital, Toronto, Ontario, Canada.
• Can J Surg. 2007 Jun 1;50(3):214-6.

ObjectiveDoes supplemental perioperative oxygen reduce the risk of surgical wound infection after colorectal surgery?DesignRandomized controlled trial.SettingMulticentre trial that included 14 hospitals in Spain.Patients300 patients aged 18-80 years who underwent elective colorectal resection. Patients who had surgery performed laparoscopically or who had minor colon surgery were excluded.InterventionPatients were randomly allocated to either 30% or 80% fraction of inspired oxygen (FiO2) intraoperatively and for 6 hours postoperatively. Anesthetic treatment and antibiotic administration were standardized.Main Outcome MeasureSurgical site infection (SSI) as defined by the Center for Disease Control.ResultsSSI occurred in 35 of 143 patients (24.4%) who were administered 30% FiO2 and in 22 of 148 patients (14.9%) who were administered 80% FiO2 (p = 0.04). The risk of SSI was 39% lower in the 80% group (relative risk [RR], 0.61; 95% confidence interval [CI], 0.38-0.98) versus the 30% FiO2 group.ConclusionsPatients receiving supplemental oxygen have a significant reduction in risk of surgical site infection.

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