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Eur. J. Clin. Pharmacol. · Jan 1997
Randomized Controlled Trial Multicenter Study Clinical TrialEvaluation of ibuprofen versus aspirin and paracetamol on efficacy and comfort in children with fever.
- E Autret, J Reboul-Marty, B Henry-Launois, C Laborde, S Courcier, J M Goehrs, G Languillat, and R Launois.
- Clinical Pharmacology Department, Bretonneau Hospital, Tours, France.
- Eur. J. Clin. Pharmacol. 1997 Jan 1;51(5):367-71.
ObjectiveWe compared efficacy and impact on the comfort of ibuprofen (7.5 mg/kg per dose), aspirin (10 mg/kg/dose) and paracetamol (10 mg/kg per dose) on children with fever aged 6-24 months in an open, randomised study with three parallel groups.MethodsThe main criterion for efficacy was area under the curve (AUC) of percentage temperature reduction. Comfort was assessed on scores depending on general behaviour and degree of relief. General behaviour was assessed on a verbal scale and on a visual analogue scale (VAS) and the degree of relief was assessed in relation to baseline on a verbal scale.ResultsThe efficacy of ibuprofen was better than that of aspirin or paracetamol. In spite of more adverse events, the comfort scores were significantly in favour of ibuprofen 6 h after the first dose of treatment.
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