• Y Fujii, H Tanaka, and M Ito.
• Department of Anesthesiology, Toride Kyodo General Hospital, Toride City, Ibaraki, Japan.
• Ophthalmology. 1999 Sep 1;106(9):1713-5.

ObjectiveTo evaluate the efficacy of oral granisetron for the prevention of postoperative vomiting in children undergoing strabismus surgery.DesignProspective, randomized, double-masked, placebo-controlled study.ParticipantsA total of 120 children, 4-10 years of age, scheduled for elective strabismus surgery.InterventionPatients received oral placebo or granisetron at three different doses (20 microg/kg, 40 microg/kg, 80 microg/kg) 1 hour before surgery.Main Outcome MeasuresA complete response, defined as no vomiting, no retching, and no need for rescue antiemetic medication, during the first 24 hours after anesthesia was recorded.ResultsA complete response during 0-24 hours after anesthesia occurred in 33% of those who received placebo, 40% who received granisetron 20 microg/kg, 83% who received granisetron 40 microg/kg, and 87% who received granisetron 80 microg/kg (P < 0.05, overall Fisher's exact probability test).ConclusionPreoperative oral granisetron, in doses more than 40 microg/kg, is effective for preventing vomiting after strabismus surgery in children.

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