• Ophthalmology · Sep 1999

    Randomized Controlled Trial Clinical Trial

    Preoperative oral granisetron for the prevention of vomiting after strabismus surgery in children.

    • Y Fujii, H Tanaka, and M Ito.
    • Department of Anesthesiology, Toride Kyodo General Hospital, Toride City, Ibaraki, Japan.
    • Ophthalmology. 1999 Sep 1;106(9):1713-5.

    ObjectiveTo evaluate the efficacy of oral granisetron for the prevention of postoperative vomiting in children undergoing strabismus surgery.DesignProspective, randomized, double-masked, placebo-controlled study.ParticipantsA total of 120 children, 4-10 years of age, scheduled for elective strabismus surgery.InterventionPatients received oral placebo or granisetron at three different doses (20 microg/kg, 40 microg/kg, 80 microg/kg) 1 hour before surgery.Main Outcome MeasuresA complete response, defined as no vomiting, no retching, and no need for rescue antiemetic medication, during the first 24 hours after anesthesia was recorded.ResultsA complete response during 0-24 hours after anesthesia occurred in 33% of those who received placebo, 40% who received granisetron 20 microg/kg, 83% who received granisetron 40 microg/kg, and 87% who received granisetron 80 microg/kg (P < 0.05, overall Fisher's exact probability test).ConclusionPreoperative oral granisetron, in doses more than 40 microg/kg, is effective for preventing vomiting after strabismus surgery in children.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…