• A Jacot, B Bissonnette, J B Favre, and P Ravussin.
• Service d'anesthésiologie, CHU Vaudois, Lausanne, Suisse.
• Ann Fr Anesth Reanim. 1998 Jan 1;17(3):220-6.

ObjectiveTo determine the effect of ondansetron on intracranial pressure (ICP), mean arterial pressure (MAP) and cerebral perfusion pressure (CPP).Study DesignProspective, comparative, randomized double-blind study.PatientsTwenty-six patients undergoing intracranial surgery.MethodInduction was obtained with propofol (1-2.5 mg.kg-1), fentanyl (1.5 micrograms.kg-1) and pancuronium (0.1 mg.kg-1), and maintenance was achieved with propofol and fentanyl. Intermittent positive pressure ventilation was used to ensure mild hypocapnia at 35 +/- 2 mmHg. Positioning of the patient was followed by 15 minutes steady-state. Patient received thereafter either 8 mg ondansetron or a placebo intravenously. The ICP was measured using a lumbar malleable spinal needle. CPP was calculated using the formula CCP = MAP-ICP. All variables were measured every minute for 15 minutes.ResultsThe ICP, MAP and CPP did not differ between the two groups. There were no differences in the highest ICP values in patients receiving either ondansetron or placebo (11 +/- 5 versus 9 +/- 5, mean +/- SD), respectively.ConclusionIntravenous administration of 8 mg ondansetron affects neither cerebral hemodynamics nor ICP.

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