• Helmut Laufs, Ulrike Lengler, Khalid Hamandi, Andreas Kleinschmidt, and Karsten Krakow.
• Department of Neurology, Johann Wolfgang Goethe-University and Brain Imaging Center Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany. helmut@laufs.com
• Epilepsia. 2006 Feb 1;47(2):444-8.

PurposeTo illustrate a functional interpretation of blood oxygen level-dependent (BOLD) signal changes associated with generalized spike-and-wave discharges in patients with absence seizures and to demonstrate the reproducibility of these findings in one case.MethodsIn a 47 year-old patient with frequent absence seizures, BOLD signal changes during generalized spike-and-wave discharges (GSWD) were mapped by using simultaneous and continuous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) at 1.5 T and 6 months later at 3 T. GSWDs were modeled as individual events and as blocks.ResultsThe patient studied exhibited frequent generalized spike-wave activity with temporal properties ideal for study with EEG/fMRI. Highly reproducible GSWD-associated fMRI signal decreases (deactivations) were seen in bilateral frontal and temporoparietal cortices and the precuneus, in addition to activations in occipital cortex and, at 3 T, the posterior thalamus.ConclusionsThe GSWD-associated changes seen here involve cortical regions that have been shown to be more active at conscious rest compared with sleep and with various types of extroverted perception and action. These regions have been proposed to constitute the core of a functional "default mode" system. We propose that the findings of deactivation of this distributed brain system during GSWDs mirrors the clinical manifestation of GSWDs (i.e., absence seizures). Furthermore, we suggest that these deactivations may reflect the functional consequences of GSWDs on physiologic brain activity at rest rather than direct hemodynamic correlates of epileptic discharges.

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