• Neurol. Sci. · Dec 2009

    Clinical Trial

    Lack of effect of cannabis-based treatment on clinical and laboratory measures in multiple sclerosis.

    • Diego Centonze, Francesco Mori, Giacomo Koch, Fabio Buttari, Claudia Codecà, Silvia Rossi, Maria Teresa Cencioni, Monica Bari, Stefania Fiore, Giorgio Bernardi, Luca Battistini, and Mauro Maccarrone.
    • Clinica Neurologica, Dipartimento di Neuroscienze, Università Tor Vergata, Via Montpellier 1, 00133 Rome, Italy. centonze@uniroma2.it
    • Neurol. Sci. 2009 Dec 1;30(6):531-4.

    AbstractThe endocannabinoid system (ECS) is involved in the pathophysiology of multiple sclerosis (MS), and relief from pain and spasticity has been reported in MS patients self-medicating with marijuana. A cannabis-based medication containing Delta(9)-tetrahydrocannabinol and cannabidiol (Sativex) has been approved in some countries for the treatment of MS-associated pain. The effects of this pharmaceutical preparation on other clinically relevant aspects of MS pathophysiology, however, are still unclear. In 20 MS patients, we measured the effects of Sativex on clinically measured spasticity and on neurophysiological and laboratory parameters that correlate with spasticity severity or with the modulation of the ECS. Sativex failed to affect spasticity and stretch reflex excitability. This compound also failed to affect the synthesis and the degradation of the endocannabinoid anandamide, as well as the expression of both CB1 and CB2 cannabinoid receptors in various subpopulations of peripheral lymphocytes.

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