• Mayo Clinic proceedings · Aug 2000

    Case Reports

    Recalcitrant pyoderma gangrenosum treated with thalidomide.

    • G L Federman and D G Federman.
    • Department of Dermatology, Yale University School of Medicine, New Haven, CT 06516, USA.
    • Mayo Clin. Proc. 2000 Aug 1;75(8):842-4.

    AbstractPyoderma gangrenosum is a painful, noninfectious, ulcerating skin disorder often associated with systemic disease. Thalidomide has been used to treat many inflammatory dermatologic conditions and has been reintroduced in the United States to treat immune-modulated diseases such as pyoderma gangrenosum. The patient described, a 47-year-old man, had histologically confirmed pyoderma gangrenosum that did not respond to treatment with several courses of methylprednisolone. The ulcer healed with 10 weeks of oral thalidomide administration.

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