• Suat Türkoğlu, Mehmet Hamdi Muz, Reşat Ozercan, Ferit Gürsu, and Gamze Kırkıl.
• Department of Biochemistry, Faculty of Medicine, Firat University, Elazig, Turkey. gamkirkil@yahoo.com.
• Tuberk Toraks. 2012 Jan 1;60(2):101-7.

IntroductionThis study, we aimed to investigate the protective effect of lycopene in lung injury rat model.Materials And MethodsTwenty eight Wistar rats were enrolled into the study. Control group (n= 7) were applied PBS + ethanol (9/1). A single dose of 100 mg/kg oleic acid (OA) intravenously was administrated to OA group (n= 7). One mL of corn oil was given daily to corn oil + OA group (n= 7) by gavage for five weeks. Lycopene was given by gavage to lycopene + OA group (n= 7) for five weeks. At the end of the 5th weeks, OA were given. Four hour after OA administration, lung tissue, blood samples were taken. Malondialdehyde, superoxide dismutase, glutathione-peroxidase, catalase levels were determined.ResultsMalondialdehyde levels of serum, lung tissues were increased in OA, corn oil + OA groups than control, where as decreased to controls levels in lycopene + OA group (p< 0.05). Superoxide dismutase, glutathione-peroxidase activities of serum, tissue increased moderetaly or they were closed with control values. There was significant increase in lycopene + OA group values. Histopathological examination of control group was normal. OA, cornoil + OA groups had perivascular, alveolar edema, hemorrage, prominent neutrophil infiltration, destruction in alveolar structure. Lycopene + OA group had less neutrophilic infiltration, perivascular, alveolar edema.ConclusionLycopene rich diet may have an important role preventing damages in lungs.

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