• Pol. Arch. Med. Wewn. · Jan 2012

    Review

    Microparticles: a component of various diseases.

    • Miroslav Budaj, Zuzana Poljak, Ivan Ďuriš, Martin Kaško, Richard Imrich, Martin Kopáni, Lenka Maruščáková, and Ivan Hulín.
    • Institute of Normal and Pathological Physiology, Comenius University in Bratislava, Bratislava, Slovakia. miroslav.budaj@fmed.uniba.sk
    • Pol. Arch. Med. Wewn. 2012 Jan 1;122 Suppl 1:24-9.

    AbstractMicroparticles (MPs) are phenotypically and functionally heterogeneous population of microvesicles. Although MP formation represents a physiological phenomenon. A multitude of pathologies, including inflammatory and autoimmune diseases, atherosclerosis, and malignancies, are associated with a considerable increase in circulating MPs. Elevated levels of platelet‑, endothelial cell‑, and monocyte‑derived MPs have been documented in a number of clinical conditions in which vascular dysfunction and inflammation are important pathophysiological mechanisms (e.g., coronary artery disease or thrombotic microangiopathies). Knowledge of the functional properties of MPs will contribute to a better understanding of the pathological mechanisms of communication between cells and of the causes of various diseases.

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