• Shahrbanoo Shahbazi, Alireza Talei, Afsaneh Besharati, and Seyed Javad Shamsnia.
• Department of Anesthesiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. sh_shahbazi@yahoo.com
• Middle East J Anaesthesiol. 2004 Jun 1;17(5):969-74.

Background And AimsIn open-heart surgery, cardiopulmonary bypass (CPB) can cause a rise in the level of stress hormones such as cortisol. Reducing this hormonal response is beneficial in the recovery period. Anesthetic agents and methods used in such operations have different effects on this response. In the present study two agents (morphine and sufentanil) routinely used for the cardiac surgery in Nemazi Hospital were compared regarding their effect on the serum cortisol levels.Materials And MethodsThirty patients undergoing coronary artery bypass grafting (CABG) in Nemazi Hospital were selected and divided into two groups. Group 1 (16 patients received morphine in a dose of 1 mg/kg) and Group 2 (14 patients received sufentanil in a dose of 5 microg/kg). Serum cortisol levels were measured before induction of anesthesia, after tracheal intubation, after initiation of CPB and twelve hours after the termination of operation.ResultsMorphine and sufentanil both lowered the serum cortisol level during the operation. However, twelve hours after the operation, cortisol levels in both groups were higher than those taken in the previous set times.ConclusionNeither morphine nor sufentanil in the mentioned doses could reduce the endocrine response in the postoperative period, and thus have no preference, in cardiac surgery.

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