• World J. Gastroenterol. · Apr 2015

    Review Meta Analysis

    Integrin antagonists are effective and safe for Crohn's disease: a meta-analysis.

    • Wen-Song Ge and Jian-Gao Fan.
    • Wen-Song Ge, Jian-Gao Fan, Department of Gastroenterology, Shanghai Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
    • World J. Gastroenterol. 2015 Apr 21;21(15):4744-9.

    AimTo evaluate the efficacy and safety of integrin antagonists, including natalizumab and vedolizumab, in Crohn's disease (CD).MethodsWe carried out a literature search in PubMed, MEDLINE, EMBASE and the Cochrane Library to screen for citations from January 1990 to August 2014. Data analysis was performed using Review Manager version 5.2.ResultsA total of 1340 patients from five studies were involved in this meta-analysis. During 6-12 wk treatment, integrin antagonists increased the rate of clinical response and remission with OR = 1.69, 95%CI: 1.37-2.09 and 1.84, 95%CI: 1.44-2.34, respectively. No significant difference was found between integrin antagonists and placebo treatments regarding their adverse reactions (OR = 1.07, 95%CI: 0.83-1.38) and serious adverse reactions (OR = 0.81, 95%CI: 0.57-1.15).ConclusionThe results prove the efficacy and safety of integrin antagonists for CD treatment, although the treatment strategies varied.

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